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Alanine scanning mutagenesis revealed several residues that influence activity and specificity, including G296, Y398, and S586

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SEMA+CAGRI Sema/Cagri is a dual-compound research blend combining a long-acting GLP-1 receptor agonist with a long-acting amylin analog, allowing researchers to examine complementary incretin and amylin receptor pathway interactions simultaneously in controlled laboratory models