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As people age, the ability to absorb vitamin B12 from food often diminishes due to decreased stomach acid production

208 Also, with repeated doses of cyclophosphamide, the plasma half-life of parent compound becomes progressively shorter, 196 , 209 and that of 4-hydroxycyclophosphamide increases, which indicates that cyclophosphamide can induce the P450 enzymes responsible for its metabolism

Kantono, M., & Guo, B

(2022) Review GH fragment biology overview
