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A few commenters described these items as part of a build of a garment/solution and suggested they have unique HCPCS codes to support the build. Several commenters requested clarification on the term padding suggesting this should be itemized for the sake of comprehensiveness and include foam sheets, foam rolls, cotton or synthetic padding, stockinette, customized foam cutouts, and chip pads as well as Swell Spots or similar quilted items to be used under clothing

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At optimal concentrations, GHK-Cu increases mRNA production for collagen types I and III, elastin, proteoglycans, and glycosaminoglycans, while laboratory studies show that topical application for 12 weeks improves collagen production in 70% of subjects compared to 50% with vitamin C and 40% with retinoic acid

The protocol was approved by the Dutch Animal Ethics Committee