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Description
The flavonoid morin modulates key pathways governing inflammation and cell survival, offering multi-target pharmacological effects
Int J Biol Macromol 267:131342
4l, Supplementary Data 5a), we confirmed that rapamycin inhibited mTOR-MYC signaling/targets as well as downregulated all major metabolic pathways (OXPHOS, glycolysis and fatty acid metabolism) and T cell activation/effector pathways (IL-2-STAT5, IL-6-JAK-STAT3, allogenic activity, and interferon response)
These signatures were detectable prior to intervention and were consistent across analytical approaches and patient cohorts
