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Histamine Overload and MCAS Flares: As a key component of Phase II liver detoxification, glutathione accelerates the clearance of circulating histamine and inflammatory cytokines, helping to reduce flushing, itching, and sudden allergic-like reactions

10.1074/jbc.REV118.002806 31 GergsU.BrucknerT.HofmannB.NeumannJ

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For example, supplementation with vitamin D (60,000 IU of vitamin D orally once weekly for 1 month, and then 60,000 IU once a month for the next 2 months) and calcium (1000 mg/day) decreased chronic non-specific musculoskeletal pain in a study conducted on 50 hypovitaminosis D patients [104]