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MMA rises when B12 is functionally lacking inside the cells and is the more specific of the metabolic markers

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Degradation of Neurotransmitters by MAO and COMT SAM is also used to degrade neurotransmitters via monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT)

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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

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