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Research shows that Graves' disease is associated with significantly elevated oxidative stress and increased ROS generation

Lipopolysaccharide (LPS), a component of bacterial cell walls, binds to TLR4, which partners with NOX4 to promote ROS production and subsequent activation of NFB in HEK293T cells [282]

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By blocking DAT, NET, and SERT, tesofensine increases synaptic concentrations of dopamine, norepinephrine, and serotonin in brain regions controlling appetite and energy balance