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Another randomized controlled trial of patients undergoing surgery for esophageal cancer showed that EPA-enriched enteral nutrition, given preoperatively and postoperatively, significantly protected against lean body mass (with significantly less postoperative lean body mass loss in the EPA group), resulting in an overall weight loss of only about 1.2 kilograms (compared to 1.9 kilograms in the control group) (74)

However, the passage of 5-methyl-THF through the methionine cycle is limited, especially in situations with high intracellular 5-methyl-THF levels

Clin Sci (Lond) 110.2 (2006): 255263 Okamoto LE, et al

Parisy et al., 2006