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This supports the premise that minimally invasive ISF sampling can serve as a reliable surrogate for systemic pharmacokinetics
There are three main ways: Methylmalonic acid (MMA) MMA is one of the most useful markers for detecting B12 deficiency, because B12 helps convert methylmalonyl-CoAone of the forms of MMAinto succinyl-CoA
Fuxe et al., 2015
