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Further well-designed, multicenter randomized controlled trials employing standardized and sensitive apnea detection methods are essential to definitively evaluate this potential application (45, 78)

PMID: 30281517 7 Primary and maternal 3-methylcrotonyl-CoA carboxylase deficiency: insights from the Israel newborn screening program

The enzyme acyl-CoA synthase converts long chain fatty acids to fatty acyl-CoAs, which are subsequently converted to acylcarnitines by the enzyme carnitine palmitoyltransferase I (CPT I) localized in the outer mitochondrial membrane [1, 43]