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doi: 10.1093/molehr/gaac018 109 PrietoLQuesadaJFCamberoOPachecoAPellicerACodoceoRet al
This poses significant challenges for the long-term success of gene therapy, mainly in patients receiving low doses of AAV, such as children, as tissue growth and proliferation may dilute the vector genome, potentially worsening symptoms over time
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Niacin is a cofactor of nicotinamide adenine dinucleotide and NADPH, which are necessary for the scavenging of oxidants and needed for GSH regeneration (157)
