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The compound regulates miRNA expression through AMPK signaling pathway activation and chromatin remodeling, with PDCD4 protein levels increasing by 60% following miR-21 inhibition (101)
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DHODH is central to the de novo pyrimidine synthesis pathway, catalyzing the conversion of dihydroorotate to orotate as a crucial step, which is the only reaction within this pathway involving a mitochondrial enzyme (168)

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