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Description
If body composition or glucose regulation is off, GLP-1 therapy does more for healthspan than any peptide, with phase 3 evidence behind it (14.9% weight loss in STEP 1, Wilding 2021 NEJM

Under continuous weekly exposure the receptor desensitizes: semaglutide is a full beta-arrestin recruiter (GLP-1R Emax 106%, Coskun 2022 Table S2

Referenced Citations Drmic D

TB-500's longer half-life supports less frequent dosing than BPC-157
