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The small intestine of the control, vehicle, and solvent groups showed normal histological structures of the intestinal layers and villi (Fig

In addition to the dietary nutrients entering the gastrointestinal tract, other substances from endogenous sources, such as saliva, bile, urea, glutathione, etc., simultaneously enter into the lumen where they can be metabolized by the microbiota (59)

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Meanwhile, the prodrug of triptolide, has been developed in clinical trials for patients with advanced solid tumors (NCT03129139) and refractory pancreatic malignancy (NCT03117920 and NCT04896073)