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Relying on a single biomarker, whether derived from neuroimaging, biofluids, electrophysiology, or clinical scales, has proven insufficient to capture the complexity of neuronal injury and recovery [586, 587]

Evidence: Green tea consumption is associated with lower serum folate in pregnant women Animal studies show neurodevelopmental effects from high-dose green tea Some studies report increased neural tube defect risk with daily tea consumption Who should avoid: Pregnant women (especially during the periconceptional period) Children with neurological or developmental issues Anyone with diagnosed cerebral folate deficiency Why Standard Treatment Falls Short The standard approach focuses almost entirely on prescription Leucovorin (folinic acid)typically 5-50 mg daily

Annu Rev Plant Physiol Plant Mol Biol 50:601639