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glutathione reduces melanocyte production The critical role of redox homeostasis towards oxidation in ermanin-induced melanogenesis Glutathione IV Therapy for Skin
Description
Trends Mol Med (2022) 28:7979
Lifestyle & Environment: Exposure to pollution, smoking, alcohol use, poor sleep, and high stress can significantly deplete glutathione levels
Kucharczyk et al., 2023)
In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10
