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Aside from limiting the formation of aggregates, the polarity of these spacers also alter the interaction of the ADCs with permeability glycoprotein (Pgp) which is a major cause of multi-drug resistance (MDR) by the tumor cells (28)

J Am Chem Soc 144:72837294 Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A et al (2019) Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma

[DOI] [PMC free article] [PubMed] [Google Scholar] 263.Archer SN, et al

This form of glutathione is particularly effective for those looking to maximize their supplementation